RESEARCH

MULTICOMPONENT REACTIONS

The rapid assembly of complex and diverse (hetero)cyclic frameworks is an important pursuit in organic chemistry. To build such structurally complex scaffolds starting from simple and abundant building blocks, multicomponent reactions (MCRs) has emerged as a powerful approach. Multicomponent reactions are one-pot processes in which three or more starting materials form a product that incorporates the structural features of each reagent. In addition, by generating structural complexity in a single operation from three or more reactants, MCRs provide efficient and atom-economic routes for the synthesis of target compounds. They have played important roles in modern synthetic organic chemistry including drug-discovery research. Moreover, MCR followed by a cascade cyclization and/or further structural modification increases the molecular diversity and complexity in a fast and often experimentally simple fashion.

The core idea is to study various MCRs and post MCR strategies towards complex heterocycles.